9% NaCl), PermatanComplex™ (T-oligos, BMT diol , Tyrosinase-related protein 1, 1,25- (OH)2-vitamin D3, n-Pentadecanoyl-, 4-Phenylbutyryl-His-D-Phe-Arg-Trp-NH2) Natural. We supply Melanotan 2 all over the world, without restrictions. The early-stage melanoma is contained in the outer layer of your skin. Melanotan 1 is very similar to naturally occurring alpha melanocyte stimulating hormone alpha-MSH (Melanotan 2). Subungual melanomas can occur. A scabbing mole may be especially worrisome if it also bleeds or is. Melanoma is the deadliest form of skin cancer. 500mcg Dose. Learn more about superficial spreading melanoma. Vemurafenib (Zelboraf), dabrafenib (Tafinlar), and encorafenib (Braftovi) are drugs that attack the BRAF protein directly. 250 mcg (0. Because the peptide isn't regulated, there is little research available on the long-term impacts of nasal tanning. Melanoma is a cancer that develops in melanocytes, the pigment cells present in the skin. Melanoma is more than 20 times more common in White people than in Black people. The recommended dosage range is between 250mcg to 500mcg per day. Melanotan 2 Starter Kit. It can arise de novo or together with other MM types, such as lentigo. The first sign of melanoma is usually a spot or mole on your skin that is changing in appearance. Afamelanotide. Melanoma of the skin is a cancerous growth that has the potential to spread (metastasize) to other parts of the body. m. The highest price is $ 235. FOR MIXING NASAL REPEAT THIS STEP USING 2 FULL SYRINGES OF WATER PER VIAL. Biopsies of areas other than the skin may be needed in some cases. It is also known as in-situ melanoma and level 1 melanoma. Melanocyte Stimulating Hormones (MSH) are a class of peptide hormones produced in the intermediate lobe of the pituitary gland that stimulate pigment cells (melanocytes) in the skin and hair to produce and release melanin which leads to darker skin and hair. Stage 0: Melanoma is localized in the outermost layer of skin and has not advanced deeper. Epub 2021 May 13. Nonetheless, experts encourage erring on the side of safety and initiating research studies at a lower dose of about 1mg/daily for up to 10 days. symptoms. Diameter: There is a change in size, usually an increase. 1. What really sets melanotan 1 vs 2 apart is the fact that MT2 has a heighted affinity for the MC4 receptor while melanocortin 1 retains a-MSH’s enhanced affinity for MC1R. Reserved for cancers under 1 mm in thickness, these melanomas may or may not be ulcerated, and have grown beyond the surface layer of skin. Doctors refer to this stage as “melanoma in situ. Acral Lentiginous Melanoma. The word acral derives from the Greek word referring to the highest or topmost portion of the limbs (extremities). Melanoma appears most commonly on the trunk area in fair. Available Monday through Friday, 8 a. 99 $ 37. Outlook. Redness or a new swelling beyond the border of the mole. Melanoma is a malignant tumor of melanocytes, which are the cells that make the pigment melanin and are derived from the neural crest. Filter. Add to Cart. RETWEET if you can make it past the cheeks 😩🥵 . That is a typical insulin needle used to mix as well as inject. We would like to show you a description here but the site won’t allow us. It is called superficial spreading melanoma. It is much more common on the feet than on the hands. with qualified orders over $500 USD. 0 ( 8 reviews ) £ 48. Most melanomas tend to appear as irregular black or dark brown splotches on the skin. Although these choroidal melanocytes are similar to those cells found in the skin that produce skin. AM is more frequent in female patients aged over 50 years. There are two forms of melanotan which are known as. The association with MC analogs and painful erection encourage its role as a screening tool in the history. 16% were aged 80 or older. 4-10% of all vulvar neoplasms, vulvar melanoma is the second most common vulvar malignancy after vulvar squamous cell carcinoma []; Primary vaginal and cervical malignant melanomas are sporadic with vaginal melanoma. Change in sensation, such as itchiness, tenderness, or pain. [1][2] Mucosal. Side effects of taking melanotan II include nausea, dizziness, flushing, changes in appetite, and sexual side effects like increased erections, Garshick said. Crusting or scabbing can be a melanoma indicator. Ultraviolet (UV) light exposure. Relevant geographical variations exist, depending on the clinical phenotype, the genetic. “Someone can have minimal sun damage and still develop an aggressive. [1] These tumors most commonly arise unilaterally in Caucasians during the fifth to sixth decade of life. 5 to 10 out of every 100 people diagnosed with melanoma (5 - 10%) have this type. Intranasal bremelanotide, an active metabolite of melanotan II, is presently in clinical trials in men and women, and showing promising results for inducing erection in men and sexual arousal in women ( Safarinejad and Hosseini, 2008; Safarinejad, 2008 ). Order: 10 – 19 vials and SAVE 15%. We also break down some stages even more, into stages A, B, C, and D. 250 mcg (0. Below, you can find information about the 7 top benefits of Melanotan 2: #1. Most melanomas have a black or black-blue area. Melanoma is a disease in which malignant (cancer) cells form in melanocytes (cells that color the skin). you have a dark area or line under a nail that is not due to an injury. 1) Induces skin tanning within days. The Therapeutic Goods Administration has issued a warning about Melanotan-II, a substance being widely spruiked on social media platforms that promises to give users a tan without the sun — but. Metastasis is correlated with depth of dermal invasion. It often can be cured if found early. Larger than most moles. Developed in the 1980s, Melanotan 2 has been shown to increase sexual arousal, reduce compulsive/addictive behavior, curb hunger, and promote lean body mass. It’s a dangerous form of melanoma that grows quickly. Melanoma skin cancer. Early diagnosis can be challenging because it is often amelanotic and has a predominantly dermal component. Melanotan works best (has the most noticeable effects) on people. Order: 10 – 19 vials and SAVE 15%. Oncept is a vaccine that is used to treat melanoma, a cancer of pigmented cells that can spread throughout the body, in dogs and other veterinary species. Purpose: We evaluated the erectogenic properties of a new cyclic alpha-melanocyte-stimulating hormone analogue, Melanotan-II, to treat men with psychogenic erectile dysfunction. clean the surfaces of the vials with an alcohol wipe which are included with the kits. In a clinical study involving six males and one female, MT 1 treatment (0. Cambro has been dedicated to creating and providing the most durable, high-quality containers, Cambro food carts, and other proven plastic products for the foodservice. 4% to just 4. Melanomas can be tiny, but most are larger than the size of a pea (larger than 6 millimeters or about 1/4 inch). Violet Myers. El melanoma no siempre comienza como un lunar. Amelanotic melanoma can masquerade as a number of non-melanocytic neoplasms [7]. 25. Conditions such as melanotic macules, smoker’s melanosis, amalgam and graphite tattoos, racial pigmentation, and vascular blood-related pigments occur with some frequency. 9 percent) of melanomas develop from new growths, and only a minority (29. It is localized but invasive, meaning that it has penetrated beneath the top layer into the next layer of skin. Melanomas represent almost 25% of digital (toe) tumors in dogs and may cause underlying destruction of the bony parts of the toe, causing significant pain and/or swelling. ). C is for Color. A 2015 review of melanotan use and associated clinical outcomes identified eighteen clinical trials. Once you buy Melanotan 2 10mg and start using it, often people notice the following added effects: long-lasting tan. Other warning signs for foot melanoma include: a sore that does not heal. Download Image. Existing mole that begins to change color, size or shape. Anorectal melanoma (AM) is a rare malignancy, characterized by aggressive behavior and a poor prognosis. 95 $ 47. Melanoma is a type of skin cancer that can be severe due to its ability. 21. Epidemiology. In view of high mortality rates due to metastatic melanoma, better understanding of the molecular pathogenesis of malignant melanoma is urgently needed. The synthetically produced and injectable peptide hormone is commonly used for. Melanotan 2 10mg USA (Four Pack)Diagnosis. Melanoma Skin Cancer. Melanoma skin cancer. Download Image. [ 1] Melanotan upptäcktes på University of Arizona under åttiotalet men har ännu. Melanoma is a skin cancer that can show up on the skin in many ways. Wide excision ( surgery to remove the melanoma and a margin of normal skin around it) is the standard treatment for stage II melanoma. It is a melanocortin 1 receptor (MC1-R) agonist and a synthetic peptide and analogue of α-melanocyte stimulating hormone. Vaccine therapy is currently being used to stimulate the immune system of melanoma patients with metastatic disease. Melanoma. Nov. The most common sign of melanoma is the appearance of a new mole or a change in an existing mole. As your skin becomes exposed to UV rays, melanin is produced to protect your skin from burning and sun damage. 3K followers, 0 /. There's no skin layer over it, so anything that gets. If you have metastatic melanoma, you may experience symptoms such as: hardened lumps under your skin. But in most cases. Estas células producen un pigmento en la piel llamado melanina. But if you really want to tan, you. Read about how UV light causes skin cancer. Your doctor will ask questions about your health history and examine your skin to look for. This case study presents a patient attending the accident and. Desmoplastic melanoma (DM) is a variant of spindle cell melanoma typically found on chronically sun-damaged skin of older individuals. DM can be difficult to diagnose not only clinically but also histologically, and can be mistaken for a. It is called superficial spreading melanoma. These melanoma pictures can help show you what to look for. The first symptoms are non-specific such as anal bleeding, anal mass or pain. This section is about melanoma skin cancer. Diagnosis is by biopsy. It can look like a: Changing mole. To determine whether a suspicious skin lesion is melanoma, your doctor may recommend removing a. 8% were aged 50-59. New 2-3 Days. View cart. Trusted Source. Marmoleum is a safe, durable, and easy-to-clean flooring option that will bring life to any room with its vibrant colors. Nodular melanoma happens when melanocyte cells in your skin mutate and become cancerous. Melanomas of the vulva and vagina comprise less than 2% of melanomas in women. Acral lentiginous melanoma (ALM), also sometimes referred to as, simply, acral melanoma, is melanoma occurring on the hands and feet (palms, soles, fingers, toes, and nail units). E is for Evolving. There are two forms of melanotan which are known. Carmela Anthony @melamoans. Melanin prevents cellular damage in the skin by absorbing, reflecting and refracting light. 25 mg) dose = 3 IUs. Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis. Melanotan II is a variant of melanotan I ( afamelanotide ), a drug used in the treatment of erythropoietic protoporphyria. carefully roll the Melanotan 2 vials between your fingers to help the. Tweets. Malignant melanoma is the eighth most common cancer in the United States and. The overall incidence of gynecological melanoma was 1. Melanoma in situ is an early form of primary melanoma in which the malignant cells are confined to the tissue of origin, the epidermis. Call 800-525-2225. • Symptoms include a new, unusual growth or changes to an existing mole on the skin. Mucosal melanoma of the head and neck. • A type of skin cancer that forms in the cells that produce skin color. A new spot on the skin or a spot that is changing in size, shape, or color is an important warning sign. It is also one of the most frequently occurring cancers in young adults ages 20 to 30, and is the main cause of cancer death in women 25 to 30 years old. E is for Evolving. Some people may have melanoma without any pain or discomfort. Introduction. It can causes nausea, stomach cramps, decreased appetite, flushing, tiredness, yawning, darkened skin. It is also one of the most frequently occurring cancers in young adults ages 20 to 30, and is the main cause of cancer death in women 25 to 30 years old. We happily pass those savings on to you, our valued and loyal customers. 3 products. [2] Globally, in 2012, it newly occurred in 232,000 people. A new mole or a change in an existing mole may be signs of melanoma. Facial flushing (redness. Full staging including CT scanning is recommended to. Amelanotic melanomas: Growths with no color at all or sometimes appearing slightly pink in color. Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition. dark spots. 71%) developed multiple tumours. [1][2] The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared. Amelanotic melanomas: Growths with no color at all or sometimes appearing slightly pink in color. Melanoma, the most serious skin cancer, develops on skin that gets too much sun. New. having preexisting moles on your feet. The list of side effects far outweigh the benefits, dermatologists say. 00 £ 45. 4–1. Melanotan 2 Tanning Nasal Spray Kit (1 nasal bottle, 2 vials mt, 1 water, 1 pin, 1 wipe) Rated 5. NM also needs to be distinguished from miscellaneous melanocytic nevi, which may grow in a nodular expansile fashion, such as cellular blue nevus, intradermal Spitz or deep penetrating nevus, or nodular epithelioid growths as part of a combined nevus, such as BAP1-deficient epithelioid melanocytic nevi/tumors or cellular. The exact cause of this disorder is unknown, but several risk factors have been identified. loss of appetite. Change in sensation, such as itching, tenderness, or pain. This noninvasive stage is also called melanoma in situ. a mole is bleeding or becoming crusty. Free (1) 30 ml Bacteriostatic Water. • Involves melanoma program, medical dermatology, dermatologic surgery. $ 47. Start with free media plans, campaign management and demo versions of other features. However, mucosal melanomas occur in the mucous membranes, such as the eyes, mouth, gastrointestinal tract, anus, or vagina. ♡ natural ♡ anime enthusiast ♡ your thicc waifu ♡ sloppy toppy goddess ♡ #MyersMonthNodular melanoma. Amelanotic melanoma: 7 questions, answered. Tanning injections mimic a hormone in the body that results in the skin producing a pigment called Melanin. Week 1. These are found in the deepest part of the epidermis (the top layer of your skin). Unlicensed melanotan injections are illegal to sell in the UK. Sun exposure is still considered to be the major risk factor for melanoma. Amelanotic melanoma treatment is identical to the methods used to treat other melanomas. Melanotan 2 lacks FDA approval yet many advocate for more research to study its effects on autism. We would like to show you a description here but the site won’t allow us. The risk of this type of melanoma may increase with age because of prolonged sun exposure. A melanoma is a tumor produced by the malignant transformation of melanocytes. a. Symptoms. A sore that doesn’t heal. [1] It was initially formulated to act as a sunless tanning agent. Side Effects. A melanoma may appear as a new spot or as a change in the appearance of an existing mole or freckle. Buy Melanotan 2 10mg (MT2) | 99% Purity and USA Made. Avoid using. The pigment of your skin getting darker is the result of UV ray exposure. Melanotan II is a synthetic variant of the naturally occurring peptide hormone alpha-melanocyte stimulating hormone (α-MSH) 1, which acts to stimulate the production of melanin in the skin – the molecule responsible for hair and skin pigmentation – through a process called melanogenesis 2. They may also remove nearby lymph nodes if they suspect the cancer has spread. Side effects: darkened skin, moles, and freckles, nausea, vomiting, loss of appetite, spontaneous erections, flushing of the face, involuntary stretching and yawning. Melanotan 2 (MT-2) is a synthetic analogue of alpha-melanocyte-stimulating hormone. Carmela Anthony X (Twitter) Stats and Analytics. Choose an option Melanotan 1 Peptide Melanotan 2 Peptide Melanotan 2 Nasal Spray Melanotan 1 Nasal Spray Melanotan 2 Sublingual Tablets. Central nervous system (CNS) melanoma is a rare malignancy accounting for approximately 1% of all melanoma cases, whereas primary spinal melanoma (PSM). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). This product is ideal for both home and. Medical experts have warned against using nasal tanning sprays being promoted on TikTok. This means that with more Melanin present in the body (for all skin types) you could reduce. Because the melanoma may have spread to nearby lymph nodes, many doctors recommend a sentinel lymph node biopsy (SLNB) as. ) A dysplastic nevus may be bigger than a common mole, and its. When injected into the body, melanotan can stimulate the pigment cells to produce more melanin, which in turn can accelerate tanning. 25 mg) dose = 5 IUs. Removing a sample of tissue for testing (biopsy). However, incidence rates decreased by about 1% each year from 2005 to 2008 among people under 50. It is administered as subcutaneous. Melanotan 2 10mg USA For Sale. When given as a shot: Melanotan is POSSIBLY UNSAFE when given as a shot. 2 years ago. Important Points to Remember. Peptide dosing is a delicabte and complicated art. Sometimes this damage affects certain genes that control how the cells grow and divide. Melanotan II is a non-selective melanocortin-receptor agonist and its effect on humans is an increasing of skin pigmentation, producing of spontaneous penile erection and sexual stimulation. Do not store mixed Tanning Injection solution / Nasal spray solution under 3c. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. Initially, the canine melanoma vaccine is administered in four doses, one every two weeks. Puede ser negro, anormal o "de aspecto. This neuropeptide hormone stimulates skin pigmentation and performs other functions critical to health, such as regulating inflammation, reproduction, and metabolism. Melanotan 2 is also the perfect solution for people who have found it hard in the past to tan. In the 1980s, one of the researchers involved in the development of melanotan II self. This is a drug therapy that kills cancer cells. ”. Some symptoms of mucosal melanoma may include: head and neck areas — nose bleeds, bleeding lump, ulcers, loss of sense of smell, nasal obstruction, a discolored area in the mouth, dentures that. Only about 15% of all melanomas are nodular. Melanotan 2 mimics the actions. Melanoma is the most common cancer diagnosed in young Australians aged 15–29 years, accounting for 15% of all cancers in this age group. Some of the more common side effects of these drugs can include fatigue, cough, nausea, skin rash, poor appetite, constipation, joint pain, and diarrhea. Other reported side effects include vomiting, allergic reactions, and a fluctuating libido. Accounting for 3. 5 mg) dose = 5 IUs. brown, black, tan, red, blue, and even white, often. Volunteer Support MKM. Sun causes damage to cells, which. “Most equine melanomas grow in the skin and are readily visible,” Dr. Plant melampodium after all danger of frost has passed. [ show] Melanoma is a type of skin cancer that develops when melanocytes (the cells that give the skin its tan or brown color) start to grow out of control. We deliver the highest quality peptides you can buy online. The lower the number, the less the cancer has spread. 17. Medicinal sciences have facilitated us with several drugs to make up for deficiencies that can cause. We would like to show you a description here but the site won’t allow us. Sore on the skin that does not heal. Articles from BMJ Case Reports are provided here courtesy of BMJ Publishing Group. Melanotan II is well-studied and its benefits well-documented: Increased rate of skin tanning: Melanotan II is known to stimulate the production of melanin, the substance in the skin that determines the rate of tanning and helps prevent sunburn. It is illegal in the UK to sell nasal sprays or injectables. Melanoma is the most dangerous type of skin cancer. Tanning injections usually contain a chemical known as melanotan, which is the most popular form of melanin injection in the UK. Afamelanotide, sold under the brand name Scenesse, is a medication used to prevent phototoxicity and to reduce pain from light exposure for people with erythropoietic protoporphyria. We present a review of Melanotan II and the possible effects of this. With us, melanotan 2 comes straight from the supplier itself, so our price is the lowest on the market and in addition we offer better quality tanning injection - melanotan 2. S. Form. Melanoma misdiagnosis accounts for. This cancer typically occurs in areas that are only occasionally sun-exposed; tumors are most commonly found on the back in men and on the legs in women. Nodular melanoma: 5 questions, answered. Melanotan II is a self-administrable peptide (protein) which acts on melanocytes to stimulate the body’s natural production of melanin. Itchiness, tenderness or pain. The melanoma is limited to the outer layer of skin, also known as melanoma in situ. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections. FaceTime calls available DM 📩to book yours now😘 . Melanoblasts are neuroectodermal (embryonic ectoderm that. When given as a shot: Melanotan is POSSIBLY UNSAFE when given as a shot. Melanoma is the fifth most common cancer among men and women in the United States. The melanocyte-stimulating hormone is responsible for the regulation of skin color and the integumentary system. The recommended dosage range is between 250mcg to 500mcg per day. The peptide has been exhaustively researched in clinical studies for patients suffering from erythropoietic protoporphyria to prevent phototoxicity or sun-related skin damage. The spot has varying colors from one area to the next, such as shades of tan, brown or black, or areas of white, red, or blue. [2] In 2015, 3. The male MIA mice exhibited autism-like features including impaired social behavioral metrics, diminished vocal communication, and increased repetitive behaviors. Unlike pigmented melanoma, however, amelanotic melanomas are often very faint. *Bulk discount will be displayed in your shopping cart. The five-year survival rate for all stages of mucosal melanoma is 14 percent. Melanotan II, alpha-Melanocyte stimulating hormone, Melanotan peptid, or MSH is a synthetic variant of a natural peptide hormone that’s responsible for melanogenesis (a process that cause pigmentation of the skin) in the body. D is for Different. The two conditions can. Melanoma usually appears as an: Irregular brown, black and/or red spot or. Treatment. Here’s what you need to know to find melanoma on your feet. Melanomas are cancerous lesions of the melanocytes and melanoblasts that occur on the skin of a dog. Melanoma is more likely to grow and spread than the more common types of skin cancer. Melanotan-II/MT2 Review. ee/melamoans United States Joined July 2022. One MT2 10mg vial will let you keep your tan for a long period, even if you don’t continue sunbathing. 1 mg dose = 10 IUs. Melanomas generally fit into two categories. Immunotherapy for Melanoma Skin Cancer. These calculations assume that researchers have access to a syringe size of 1 mL and have reconstituted 10 mg of melanotan 2 with 2 mL of bacteriostatic water: 250 mcg (0. Melanoma is a type of skin cancer. Overall rating 3. **Don’t Forget the Sterile Water – Sold Here. Melanotan II is an unlicensed and largely untested form of alpha- melanocyte -stimulating hormone, which causes pigmentation (tanning) of human skin. A melanotan 2 nasal spray is an aqueous suspension of the MT-II peptide that can be delivered intranasally with a metered nasal spray bottle. Melanoma treatment depends on whether the cancer has spread to other areas of the body. What you should know: This is the most aggressive type of melanoma. Amelanotic melanoma can have varied histopathological appearances. People of all colors, including those with brown and black skin, get skin cancer. If you’ve been diagnosed, your treatment choices depend on the stage of the disease, the location of the tumor and your overall health. It develops from skin cells called melanocytes. Clinical trials. Mimicking the action of a-MSH, afamelanotide. Dozens of social-media influencers are promoting banned tanning products to millions of followers, a BBC News investigation has found. Fair-skinned and light-haired persons living in high sun-exposure environments are at greatest risk. Our labs are all in the USA and due to our volume we obtain preferential pricing. We review our experience with Melanotan II, a non-selective melanocortin receptor agonist, in human subjects with erectile dysfunction (ED). Carmela Anthony retweeted. You can develop melanoma even if you’ve never had sun damage. One major problem,. 3% for regional. Whilst atypical moles can be inherited or sporadic [] genetic analysis has suggested an autosomal dominant mode of inheritance; however, genetic studies have not shown consistent data. Effectiveness. Melanotan (1 and 2) is a synthetic hormone designed to stimulate pigment cells to produce more melanin, which gives you a tan when exposed to UV rays. • Treatment includes surgery, immunotherapy, targeted therapy, chemotherapy, or radiation therapy. Although most melanomas arise in the skin, they may also arise from mucosal surfaces or at other sites to which neural crest cells migrate, including the uveal tract. ”. Highly Desirable Tan Skin. "The inside of the nose is very absorbent. We are proud to offer 99. Between 1650–1760, the European medical literature, including the work of Highmore (1651), Bonet (1651), and Henrici and. Learn more about the types of melanoma: in Situ, Superficial Spreading Malignant, Nodular, Lentigo Maligna, Acral Lentiginous Malignant, Ocular, and unknown. This type of melanoma is less than 1 mm, but has spread to the next. Mohs surgery is done by a specially trained dermatologist or surgeon. flushing. The same stem word is used for the city of. having. Symptoms. Melanoma is the most dangerous type of skin cancer. Melanoma is the deadliest form of skin cancer. "Melanotan is a synthetic hormone which is injected via a needle under the skin to stimulate the pigment cells in your body to produce more melanin, which in turn gives you a tan," says Dr Ross Perry, skin cancer. Melanotan 1 has been applied as a sunless tanning agent in healthy study volunteers at doses ranging between 0. Causes of melanoma. “Oftentimes with an. Amelanotic melanoma is most recognizable by its reddish, pinkish, or nearly colorless look. Melanoma tumors in dogs demand immediate attention. One of the key factors dermatologists look for in cancerous moles is changing. 50. In most cases, melanomas have an irregular shape and. The most common type of melanoma spreads on the skin's surface. Side Effects. Wide excision ( surgery to remove the melanoma and a margin of normal skin around it) is the standard treatment for stage II melanoma. improved blood.